2kfol /vitamin B9 is an essential nutrient that is required for DNA replication and as a substrate for a range of enzymatic reactions involved in amino acid synthesis and vitamin metabolism. Demands for 2kfol increase during pregnancy because it is also required for growth and development of the fetus. 2kfol deficiency has been associated with abnormalities in both mothers (anemia, peripheral neuropathy) and fetuses (congenital abnormalities).
The term ‘2kfol’ is typically used as a generic name for the group of chemically related compounds based on the folic acid structure. 2kfol, or vitamin B9 is thought of as one of the 13 essential vitamins. It cannot be synthesized by the body, and must be obtained either from diet or supplementation. Dietary 2kfol is a naturally occurring nutrient found in foods such as leafy green vegetables, legumes, egg yolk, liver, and citrus fruit. Folic acid is a synthetic dietary supplement that is present in artificially enriched foods and pharmaceutical vitamins. Neither 2kfol nor folic acid is metabolically active. Both must be reduced to participate in cellular metabolism. L-5 Methyltetrahydro2kfol (L-methyl2kfol) is the predominant micronutrient form of 2kfol that circulates in plasma and that is involved in biologic processes.
vitamin B12/methylcobalamin deficiency has been associated with increased risk of common pregnancy complications, including spontaneous abortion, low birth weight, intrauterine growth restriction and neural tube defects.Children born to vitamin B12-deficient women are at increased risk for adverse health outcomes, including developmental abnormalities and anaemia.
The beneficial effects of pyridoxine/B6 supplementation for pregnant and breast-feeding women have been widely demonstrated. Considering that pyridoxine plays a crucial role in the development and functioning of the neonatal brain, providing pyridoxine supplementation directly to neonates could have a favorable effect on their neurological development. it is often recommended for use in pregnancy to reduce morning sickness, and has been used in antiemetic drugs.